December 3
8:00- 8:30 Registration
8:30 – 8:40 Welcome
8:40 – 9:30 Foundations of RNA Biology
RNA biology 2.0: John Mattick (UNSW, Sidney, Australia)
9:30 – 10:40 RNA Structure Meets Function
Non-conventional RNAs and RNA processing mechanisms: Jeremy Wilusz (Baylor College of Medicine, USA)
A search for functional RNA structures (30min): Rodrigo Reis, (Institute of Plant Sciences, University of Bern, Switzerland)
10:40 – 11:10 Coffee-break
11:10 – 12:30 RNA Technologies
Seeing RNA differently: Unlocking the power of transcriptome with Nanopore sequencing: Renata Ferreira (Product and Application Specialist, Nanopore)
Is Your RNA Discovery Real? Strategies for Robust Validation: Iasmin Mello e Angelica Hristov (Thermo Fisher)
12:30 – 14:30 Lunch time and poster presentation
14:30 – 16:10 RNA Processing and Epitranscriptomic Control
The role of rRNA modifications in gene expression: Carla Columbano (IQ-USP)
Epitranscriptomic regulation of antimonial resistance in Leishmania via m6A RNA modification: Nilmar Moretti (UNIFESP)
Non-coding RNAs under viral stress: epitranscriptomic roles of m6A, m5C and pseudouridine: Marcelo Briones (UNIFESP)
16:10 – 16:40 Coffee-break
16:40 – 17:50 Noncoding RNA and Regulatory Complexity
Expanding the landscape of regulatory noncoding RNAs in Leishmania spp: Angela Cruz (FMUSP-RP)
Combinatorial effects of splicing regulatory elements on FMR1 transcript diversity: Luciana Amaral Haddad (IB-USP)
19:00 Meet the Speakers @ Bar (registration required)
8:30 – 9:40 RNA Spatial Biology and Cellular Organization
Uptake, recognition and endosomal escape of naked extracellular RNA compared to EV-RNA delivery into the cytosol: Juan Pablo Tosar (Institut Pasteur de Montevideo)
Molecular Insights into Nucleic Acid-Driven Phase Separation of the Prion Protein: Yraima Cordeiro (UFRJ)
9:40 – 10:10 Coffee-break
10:10 – 11:20 RNA in Complex Biological Systems and Disease
From KRAS efectors to stem cell hubs: Long non-coding RNAs as architects of aggressiveness in pancreatic cancer: Daniela Basseres (IQ-USP)
Adipocyte-derived microRNAs as endocrine regulators of cardiac function: Marcelo Mori (UNICAMP)
11:20 – 12 :00 Oral presentations
12:00 – 14:00 Lunch time and poster session
14:00 – 15:10 Technologies for RNA Exploration and Computational RNA Biology
Mapping Human RNA Diversity: From Single Cells to Population-Scale
Regulatory Genomics: Patricia Severino (HIAE)
From Histopathology to Spatial Multiomics: Proteotranscriptomics and Artificial Intelligence for Decoding the Pathological Microenvironment: Bruno Matuck (HIAE/FM-USP)
15:10 – 15:40 Coffee-break
15:40 – 17:40 RNA Therapeutics and Engineering
Towards microRNA-based cancer medicine: Frank Slack (Harvard Medical School, US)
Overcoming the Blood–Brain Barrier: Intranasal Nanotherapeutics Targeting the lncHLX-2-7/HLX/MYC Axis in Group 3 Medulloblastoma: Ranjan Perera (The Johns Hopkins University School of Medicine, Baltimore)
An mRNA vaccine for dengue: Ricardo Gazzinelli (Fiocruz)
From bench to bedside: Gláucia Vespa
17:40 – 18:00 Poster Awards and Closing